Bioassay of aniline hydrochloride for carcinogenicity.
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Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute, Division of Cancer Cause and Prevention, Carcinogenesis Testing Program , Bethesda, Md
Carcinogens., Aniline -- Toxicology., Coal-tar colors -- Toxico
|Series||Carcinogenesis technical report series ; no. 130, DHEW publication ; no. (NIH) 78-1385, National Cancer Institute carcinogenesis technical report series -- no. 130., DHEW publication -- no. (NIH) 78-1385.|
|The Physical Object|
|Pagination||109 p. in various pagings :|
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A bioassay of aniline hydrochlorid foe r possible carcinogenicity was conducted using Fische 34r4 rats and B6C3F1 mice. Anilin hydroe chloride was administere idn the feed, at either of two concentrations, to groups of 50 male and 50 female animal osf each species, wit thh e exception of 49 female mic ie n the high dose group.
Details Bioassay of aniline hydrochloride for carcinogenicity. EPUB
Th higeh and low. Get this from a library. Bioassay of aniline hydrochloride for possible carcinogenicity. [National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.]. The National Cancer Institute conducted a bioassay of aniline hydrochloride for possible carcinogenicity using F rats and B6C3F 1 mice (NCI ).
Aniline hydrochloride was administered in the feed to groups of approximately 50 male and 50 female animals of each species at concentrations of % (3, ppm) and % (6, ppm) of the diet for rats and % (6, ppm).
Bioassay of aniline hydrochloride for possible carcinogenicity (OCoLC) Material Type: Document, Government publication, National government publication, Internet resource: Document Type: Internet Resource, Computer File: All Authors / Contributors: National Cancer Institute (U.S.).
Division of Cancer Cause and Prevention. Dec 05, · A bioassay of aniline hydrochloride for possible carcinogenicity was conducted using Fischer rats and B6C3F1 mice. Aniline hydrochloride was administered in the feed, at either of two concentrations, to groups of 50 male and female animals of each species, with the exception of 49 female mice in the high dose group.
Bioassay for carcinogenicity of 3,2′-dimethylnitrosobiphenyl, O-nitrosotoluene, nitrosobenzene and the corresponding amines in Syrian golden hamsters Bioassay of aniline hydrochloride for carcinogenicity.
book Author links open overlay panel Stephen S. Hecht Karam El-Bayoumy Abraham Rivenson Emerich S. FialaCited by: 7. Sep 26, · Bioassay of Aniline Hydrochloride for Possible Carcinogenicity (CASRN ) Long-Term Carcinogenicity TR PDF (3MB) Bioassay of Trimethylthiourea for Possible Carcinogenicity (CASRN ) Aniline hydrochloride was tested for carcinogenicity in single experiments in mice and rats by oral administration.
No increase in tumour incidence was observed in mice. In rats, it produced fibrosarcomas, sarcomas and haemangiosarcomas of the spleen and peritoneal cavity [ref: 1].
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Bioassay of aniline hydrochloride for possible carcinogenicity. National Institutes of Health, Public Health Service, U.S. Department of Health, Education and Welfare, Bethesda, Maryland (Carcinogenesis Technical Report Series No. May 01, · In the NTP bioassays aniline HCl is reported as non-carcinogenic in the mouse but in the rat it produced fibrosarcomas, sarcomas and haemangiosarcomas of the spleen and peritoneal cavity.
The overall IARC classification of aniline is that there is limited evidence for carcinogenicity to animals (IARC, ).Cited by: Get this from a library.
Bioassay of 2,4-dimethoxyaniline hydrochloride for possible carcinogenicity. [National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.]. The genotoxicity of a variety of aniline derivatives was examined by a DNA repair test with rat hepatocytes.
Out of 37 aniline derivatives, 6 chemicals, i.e., 2,4,6-trimethylaniline (mesidine), 2,4-xylidine, 3,5-diaminobenzoic acid, 3,4-diaminochlorobenzene, 2-chloromethylaniline and 4-chloro-N-methyl-aniline, elicited positive DNA repair lindsayvanbramer.com by: Read chapter Aniline: Aromatic Amines: An Assessment of the Biological and Environmental Effects Login Register Cart Help.
Aromatic Amines: aniline-induced carcinogenicity in mice of either sex (National Cancer Institute, ~. National Cancer Institute. Bioassay of aniline hydrochloride for possible carcinogenicity.
CAS No. Abstract. The utility of information acquired from the application of genetic tests to the safety evaluation of agricultural chemicals such as animal drugs or pesticides, involves the same considerations that are used for other environmental lindsayvanbramer.com by: 4. DISCUSSION The carcinogen doses and method of administration employed in the present study were chosen for comparison to previous bioassays of o-toluidine hydrochloride [10,15].
In those assays, the lower doses were approximately the same as the dose used in the present lindsayvanbramer.com by: Aniline hydrochloride: Target Organs and Levels of Evidence for TR Bioassay of Aniline Hydrochloride for Possible Carcinogenicity (CASRN ).
The autoradiographic distribution of 14 C-aniline hydrochloride was studied in male Fischer rats following iv administration of 3, 30 or mg/kg. The highest initial concentrations of radioactivity associated with 14 C-aniline or its metabolites were found in the blood, liver, kidney, bladder and gastro-intestinal tract.
At the mg/kg dose, the spleen was the only organ that did not Cited by: and Their Relationship to the Carcinogenicity of Aniline 1 fed with aniline hydrochloride at concentrations of 3, and 6, ppm (rats), or 6, and 12, ppm (mice) in.
Aniline reacts with acyl chlorides such as acetyl chloride to give amides. The amides formed from aniline are sometimes called anilides, for example CH 3 -CO-NH-C 6 H 5 is acetanilide. At high temperatures aniline and carboxylic acids react to give the lindsayvanbramer.comance: Colorless to yellow liquid.
mg/kg aniline hydrochloride in the diet. Dietary administration of aniline hydrochloride for two years to F rats at levels of 0,and ppm produced an increased incidence of various types of splenic sarcomas in male rats in the high-dose group.
Description Bioassay of aniline hydrochloride for carcinogenicity. EPUB
Stromal hyperplasia and fibrosis of the splenic red pulp, which may represent a precursor. Sep 28, · An early NCI aniline hydrochloride cancer bioassay in Fischer rats and B6C3F1 mice demonstrated carcinogenic effects, primarily in the spleens of rats, but multiple organ sites were also involved in rats fed percent or percent aniline hydrochloride for weeks (NCI a/Ex.
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In order to assess the carcinogenic risk it is important not only to know qualitatively if a chemical is a carcinogen, but also to have an idea of its carcinogenic potency.
DNA Fragmentation: Its Predictivity as a Short Term Test. Authors; Authors and affiliations; Bioassay of aniline hydrochloride for possible carcinogenicity, Natl Cited by: Bomhard, E.M., «High-dose clastogenic activity of aniline in the rat bone marrow and its relationship to the carcinogenicity in the spleen of rats.» Archives of toxicology.
Vol. 77, no. 5, p. * There is limited evidence that Aniline Hydrochloride causes cancer in animals. It may cause cancer of the spleen and stomach cavity.
* Many scientists believe there is no safe level of exposure to a carcinogen. Reproductive Hazard * There is limited evidence that Aniline Hydrochloride may damage the developing fetus in animals.
National Cancer Institute, a Bioassay of aniline hydrochloride for possible carcinogenicity, CAS No. –04–1, NIC–CG–TR– Google Scholar National Cancer Institute, b Bioassay of o–Anisidine hydrochloride for possible carcinogenicity, CAS NO.
–29–0, NCI–CG–TR–Cited by: 6. A bioassay of o-toluidine hydrochloride for possible carcinogenicity was conducted by administering the test chemical in feed to F rats and B6C3F1 mice.
Groups of 50 rats of each sex and 50 mice of each sex were administered o-toluidine hydrochloride at one of several doses, either 3, or 6, ppm for rats and either 1, or 3, ppm. Monocyclic aromatic amino and nitro compounds [MAK Value Documentation, ] toxicity, genotoxicity and carcinogenicity, classification in a carcinogen category.
Perspectives on the mechanism of action of the splenic toxicity of aniline and structurally-related compounds 0 13 37 8 66 0 76 0 0 20 4 38 8 50 0 10 2 30 6 20 52 0 0 0 0 13 20 20 20 26 5 38 8 0 0 80 34 0 0 0 'Dose of aniline HCl expressed as mg/kg/day in the diet with approximate percent in the diet shown in parentheses Doses Cited by: High-dose clastogenic activity of aniline in the rat bone marrow and its relationship to the carcinogenicity in the spleen of rats Article (PDF Available) in Archive für Toxikologie 77(5).
NTP. TR Aniline hydrochloride (). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed Oct 02, · Testing Status of Aniline hydrochloride F; Testing Status of Aniline hydrochloride F. CASRN Long-Term Carcinogenicity.
(NIH Number: ) (Peer Review Approval 06/29/A) Bioassay of Aniline Hydrochloride for Possible Carcinogenicity (CASRN ) Rats: F/N; Mice: B6C3F1; Carcinogenesis Results. Male Rats.Early indicators of aniline hydrochloride (AH) toxicity were investigated in male Fisher rats for 1 or 4 weeks at dietary dose levels of 10, 30 or mg/kg body weight (bw)/day (actual intake at Cited by:
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